Children of Women with Rheumatoid Arthritis at Higher Risk for RA


Children of Women with Rheumatoid Arthritis May Have Higher Risk of RA and Other Diseases

R&AConnection News: Despite a growing body of evidence suggesting that maternal health is more important than maternal medications to fetal and infant outcomes, little is known about the long-term outcomes of infants born to mothers with rheumatoid arthritis (RA). Using Danish population data, researchers have shown that in utero exposure to maternal RA is associated with an increased risk of thyroid disease, and an increased risk of future RA.

Using Danish health registries that included all children born alive in Denmark between 1989 and 2013, doctors identified 2106 children born by women with RA (exposed), and 1,378,539 children born by women without RA (unexposed).

The doctors reported that children exposed to maternal RA were 2-3 more likely to develop thyroid diseases, epilepsy, and/or RA.

The risk of developing other conditions previously thought to be linked to maternal RA including anxiety, personality disorders, chronic lung disease and asthma were not significantly increased.

These findings have several limitations: 1) data only analyzed live birth data; 2) there is no report or analysis of maternal disease activity (or other factors) on fetal outcomes; and 3) data did not analyze the effects of treatment or socioeconomic status on outcomes.

Clinicians, patients and regulatory agencies are keenly focused on these outcomes and more detailed research is needed to further assess the impact of disease, drugs and health during pregnancy on long-term offspring development and outcomes.


The Danish nationwide clinical register for patients with rheumatoid a | CLEP
The Danish nationwide clinical register for patients with rheumatoid a | CLEP

The Danish nationwide clinical register for patients with rheumatoid arthritis: DANBIO Else Helene Ibfelt,1 Dorte Vendelbo Jensen,2,3 Merete Lund Hetland2,4 1Registry Support Centre (East), Epidemiology and Biostatistics, Research Centre for Prevention and Health, Rigshospitalet, Glostrup University Hospital, 2DANBIO Registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, Glostrup, 3Department of Rheumatology, Herlev and Gentofte University Hospital, Hellerup, 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Introduction: DANBIO is a research register and a data source for rheumatologic diseases (rheumatoid arthritis [RA], axial spondyloarthritis, and psoriatic arthritis) for monitoring clinical quality at the national, regional, and hospital levels. Study population: The register includes patients with rheumatologic diseases who are treated at a hospital or a private rheumatologic clinic. Registration is mandatory for all patients with RA regardless of treatment and also for patients with other diagnoses if treated with biological disease-modifying antirheumatic drugs. Since 2006, the registration has been done electronically, including patient-reported outcome measures registered electronically by the patients with the use of touch screens. Main variables: Core variables such as diagnosis, year of diagnosis, age, and sex are registered at the beginning. Data entered at later visits included the following: patient-reported outcomes for disease activity, pain, fatigue, functional status, and physician-reported objective measures of disease activity, treatment, C-reactive protein, and, when indicated, imaging. For subgroups of patients, the variables such as quality of life, sociodemographic factors, lifestyle, and comorbidity are also registered. Descriptive data: The DANBIO cohort comprised ~26,000 patients with RA, 3,200 patients with axial spondyloarthritis, and 6,200 patients with psoriatic arthritis in 2015. DANBIO has high nationwide coverage and completeness on key data variables. More than 60 original papers as well as annual reports of clinical quality (since 2005) have been published. Conclusion: DANBIO is a powerful register for research in rheumatologic diseases and furthermore serves as a Clinical Quality Register with the aim of monitoring treatment quality in patients with RA in Denmark. Keywords: rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, DANBIO register clinical quality, epidemiology

Comments (1)
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Rising Above ra
Rising Above ra


My mom doesn’t have RA, but a couple family members have autoimmune illnesses and my father had Psoriasis. So there is definitely a link I think no matter if it’s on the paternal or maternal side.

Rheumatoid Arthritis