Glucocorticoids Proton Pump Inhibitors Increase Osteoporotic Fracture Risk in RA

MedMaven

by Dr. C.H. Weaver M.D. 10/2020

Increased Osteoporotic Fracture Risk Among Patients With RA Receiving Oral Glucocorticoids and Proton Pump Inhibitors

According to study results presented at the American Society for Bone and Mineral Research Annual Meeting, held September 11 to 15, 2020 the use of oral glucocorticoids and proton pump inhibitors (PPIs) appears associated with an increased risk for developing osteoporotic fractures in patients with rheumatoid arthritis (RA).

Glucocorticoids (steroids) are commonly used in the management of RA and PPIs are frequently used at the same time to reduce the risk of ulcers. PPIs are also frequently used with NSAIDs. These study results suggest that patients should be cautious about using PPIs in combination for longer terms as they may increase the risk of bone fracture.

The current study identified 1411osteoporotic fractures in 12,351 patients with RA and the use of oral glucocorticoids and PPIs was associated with a significantly increased risk for developing osteoporotic fractures. Concomitant use of appeared to increase osteoporotic fracture risk beyond that observed with either medication alone.

Reference

Abtahi S, Driessen JHM, Burden AM, et al. Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures in patients with rheumatoid arthritis: a population-based cohort study. Presented at: ASBMR 2020 Virtual Annual Meeting; September 11-15, 2020. Poster #P-546.

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Rheumatoid Arthritis

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