A recent clinical trial evaluated the effectiveness of Actemra® (tocilizumab) for patients with rheumatoid arthritis (RA) as well as adherence to therapy. These findings were reported in the journal Rheumatology.
Actemra is a newer type of RA drug known as a biologic. Biologics interfere with specific parts of the immune system that drive inflammation. Actemra, for example, blocks the action of a protein known as IL-6. IL-6 plays a role in inflammation and can contribute to the signs and symptoms of RA by prompting white blood cells to attack certain tissues in the body.
Researchers in Sweden recently sought to evaluate the effectiveness of Actemra for patients with RA as well that rate patients stayed on treatment (adherence) and factors that influenced adherence. The study included 530 patients with RA from a Swedish registry who had been treated with Actemra between September 2008 and March 2012. Of the patients, about 65% were also on treatment with with medications known as disease-modifying antirheumatic drugs (DMARDs), which slow the progression of joint damage from RA. Twelve percent of participants hadn’t previously been treatment with biologics.
The researchers found that 79% of patients continued treatment with Actemra for six months, 64% continued for one year, and 50% continued for two years. They determined that factors linked to stopping treatment with Actemra included a low initial level of C-reactive protein (a marker of inflammation in the body), favorable self-reported status, and previous use of biologics. Simultaneous therapy with DMARDs was not linked to stopping Actemra.
According to the European League Against Rheumatism (EULAR) response criteria, 184 (47%) of patients had a good response to treatment, 133 (34%) had a moderate response, and 77 (20%) had no response. Patients with low self-reported status, a higher number of affected joints, and who weren’t on prednisone at the start of the study were more likely to have a good response to Actemra.
Researchers estimated that 64% of the 530 patients in this study would stay on Actemra for one year. Of these patients, 80% would have a measureable response to treatment. Factors that appeared linked to stopping treatment included a low level of C-reactive protein, good self-reported status, and previous treatment with biologics. Simultaneous treatment with DMARDs did not appear linked to stopping therapy with Actemra.
Reference: Forsblad-d’Elia H, Bengtsson K, Kristensen LE, Jacobsson LT. Drug Adherence, Response and Predictors thereof for Tocilizumab in Patients with Rheumatoid Arthritis: Results from the Swedish Biologics Register. Rheumatology. 2014 Dec 13. pii: keu455. [Epub ahead of print].