Failed Xeljanz I was diagnosed with RA at 26. I am now 31 and have tried and failed, plaquenil, humira, enbrel, actemra, orencia, and xeljanz. I am still on on methotrexate but that alone isnt enough to keep my symptoms at bay. I'm worried I'm running out of options since nothing seems to work for me. I fear that I'm going to get sick one day and and it turns into something like pneumonia and I'll be hospitalized. I'm looking for some advice on this. What other medication options do I have? Is there anyone else who has experienced something similar?